One in 68 Children has Autism

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Comorbidity of Autism and Seizure Disorders

February 19, 2008 5:05 am Published by

At a QSAC meeting, there arose the question of what could be the underlying causes or triggers of impulsive behaviors and cognitive impairment for individuals affected by autism and epilepsy. Is the seizure disorder worsening the autistic symptoms? How could we effectively treat the co-occurrence of these problems? These are interesting questions that I would like to invite those who read this Blog to think about.

Epilepsy is quite common in autism spectrum disorders, and it is increasingly recognized as an additional clinical problem. We evaluated the coexistence of autism and seizure disorder among the adult consumers at QSAC and found there to be a prevalence of about 30%, which correlates with studies that have reported a prevalence of 5% to 38.3% of comorbidity. These values are higher than in the normal population of children and adolescents (0.5%) (Tuchman & Rapin 2002; Clarke, et. al. 2005; Blumenfeld and Taylor, 2003).

The high prevalence of seizure disorders within autistic populations supports the notion that autism is a neurobiological disorder where the dysfunction of the nervous system is caused by genetic, metabolic, or other biological factors. Complex partial seizures and infantile spasms are probably the most common seizure types in autism and in some occasions, tuberous sclerosis. To return to the original questions, I believe that the seizure disorder is one of the risk factors that increase the cognitive impairment, adaptive and behavioral problems in individuals with autism. When autism is associated with chronic epilepsy or uncontrolled seizures this may lead to loss of neurons in the region of the hippocampus [e.g. hippocampal sclerosis]. The seizure disorder in individuals with autism may complicate the impaired cognition such as memory deficits, language impairment, visuospatial changes, decreased executive function, wandering, pacing, agitation, disruptive vocalizations, and exacerbation of repetitive behaviors. We would like to hypothesize that the comorbidity of autism and epileptic symptoms may lead to a deterioration and regression of the cognitive functions (Tharp, 2004).

Paradoxically, the impaired cognition of affected individuals could be secondary to adverse effects of antiepileptic drugs, to an underlying biological abnormality, or to the abnormal release of the cytokine protein by neurons in the hippocampus, cortex and amygdala [cytokine mediate and regulate immunity, inflammation, and hematopoiesis] (Lorenz, 2001, Jankowsky & Patterson, 1999).

This clinical treatment of affected individuals with autism and epilepsy is very complex because the efficacy of antiepileptic drugs and psychotropic medications is limited to the treatment of respectively the seizures or the specific problematic behaviors such as irritability, impulsivity, hyperactivity, repetitive behaviors, or aggression. Anticonvulsant medications could also potentially tamper with mood and behavioral disturbances frequently observed in Autism Spectrum Disorder (ASD).

The antiepileptic medications should always be adjusted against the frequency seizures episodes. Some studies argue that some individuals with autism and seizure episodes should not receive any anti-seizure medications. In some cases the management of seizure episodes has led to the minimizing of the core symptom domains of autism. In addition, some studies indicate that seizures may be part of the underlying pathophysiology of autism (Gillberg, 1991; Tuchman & Rapin 2002).

Therefore, the treatment of individuals with a comorbidity of epilepsy and autism is still obscure and clinicians should carefully evaluate the maladaptive behaviors, psychiatric symptoms, and seizure episodes, to determine the appropriate combination of medication and dosage for each affected individual (Gillberg, 1991; Tuchman, 2004; Hrdlicka, et. al., 2004).

For your viewing pleasure, I have attached below an interesting, yet – to warn you – quite long video lecture on the subject of “Seizures in children with Autism disorder” by Barry Tharp, M.D. as part of the M.I.N.D. Institute Lecture Series on Neurodevelopmental Disorders.

Accelerated Head Growth Can Help Predict Autism

February 6, 2008 3:11 pm Published by

Two new studies out of the University of Washington’s Autism Center say accelerated head growth can help pediatricians predict autism before behavioral symptoms start. According to the research, children later diagnosed with autism have normal-size heads at birth, but show accelerated head growth between six and nine months of age. The center says that this period precedes the onset of many behaviors that enable physicians to diagnose the developmental disorder. The study also indicates that this aberrant growth is present in children who have the early onset form of autism as well as those later diagnosed with the regressive type of the disorder, suggesting that an atypical biological process was in place before the regression occurred.

It is important to keep in mind that accelerated head growth doesn’t lead to a higher risk for autism. However, accelerated head growth in an infant sibling of a child with autism, who is at higher risk for the disorder, should be monitored closely.

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QSAC is a New York City and Long Island based nonprofit that supports children and adults with autism, together with their families, in achieving greater independence, realizing their future potential, and contributing to their communities in a meaningful way by offering person-centered services.

QSAC pursues this mission through direct services that provide a supportive and individualized setting for children and adults with autism to improve their communication, socialization, academic, and functional skills.